Regional Diets Targeting Gut Microbial Dynamics to Support Prolonged Healthspan

In the last 150 years, we have seen a significant increase in average life expectancy, associated with shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often largest risk factor, highlights need contemporary societies improve healthy ageing their growing silver generations. As an inevitable, non-reversing and highly individualised process, better understand how non-genetic factors like diet choices commensal gut microbes can modulate biology ageing. this review, discuss geographical ethnic variations influence habitual dietary patterns, nutrient structure, microbial profiles potential impact on human healthspan. Several genera been elderly populations but are variable across populations. It seems unlikely that universal pro-longevity microbiome exists. Rather, optimal appears be conditional functionality acting regional- ethnicity-specific trends driven by cultural food context. We also highlight observed elicit individual clustered biological responses. Finally, identify next generation avenues modify otherwise fixed host functions trajectory manipulating malleable regionally adapted, personalised intervention regimens targeted at prolonging